The Alliance Long COVID-19 Treatment Trial

The Alliance Long COVID-19 Treatment Trial

Development of a 2-stage nutraceutical treatment protocol for adults with long-COVID-19 syndrome, exploring underlying pathophysiology and treatment effectiveness

The study has been approved by the Human Research Ethics Commitee EC00436, and is registered at the ANZCTR clinical trial registry: ACTRN12622001204730p

Project explanation and objectives

A large number of people experience long-COVID symptoms persisting for weeks and months after overcoming the acute illness. Symptoms include chronic fatigue, breathlessness, joint pain, cough, neurological diseases, loss of sense of smell and/or taste.

This cohort study aims to explore the underlying causes of long COVID symptoms, and assess treatment effectiveness of a staged treatment approach of 2x 6 weeks.
This study is exploratory, and will provide important insights for protocol development for a larger cohort study.

Who can participate in this study?­­­­­­­­­­­­­­­­

You had Covid-19 and tested positive on a PCR or RAT test more than 3 months ago, and have persistent symptoms for longer than 3 months, and have a doctor’s referral.

The study involves:

  • A series of online questionnaires focusing on your symptoms and medical history
  • 3 appointments with the trial doctor over a period of 3 months
  • Blood tests at baseline and 12 weeks include standard pathology tests and the NIIM Rare Cell & Pathogen Test
  • After review of the blood test results, the trial doctor will refer you to Stage 1 intervention (0-6 weeks):
    The first 6 weeks’ treatment period will be the same for all participants, and includes food-based nutrients and supplements.
  • At 6 week assessment by online questionnaire and the trial doctor. The trial doctor will allocate you to one in three intervention groups.
  • Stage 2 (7-12th week):  The second 6 week treatment program will be conducted in 3 groups:
    Group 1: Intravenous Vitamin C therapy (IVC) –  NIIM Clinic in Melbourne, VIC
    Group 2: Kyolic & Curcumin & Omega-3 & NAC (N-acetyl-cysteine)
    Group 3: Continuation of the food-based nutritional protocol
  • Final assessment by online questionnaire and trial doctor at 12 weeks


10.12.22 update: Expressions of Interest for the Long-COVID-Trial have now closed.
If you are interested in making an appointment with a NIIM doctor specialising in Long-COVID, please ring the NIIM clinic on 03 9804 0646